Released on = May 29, 2007, 11:55 am

Press Release Author = AnaSpec Inc.

Industry = Biotech

Press Release Summary = Bioactivation of drug candidates resulting in chemically
reactive, electrophilic metabolites have always presented a major challenge to
pharmaceutical companies.

Press Release Body = May 15, 2007 - San Jose, CA

Bioactivation of drug candidates resulting in chemically reactive, electrophilic
metabolites have always presented a major challenge to pharmaceutical companies.
Moreover, the measurement of these metabolites has been hampered by the lack of an
effective quantitative method. QA-GSH is a novel new tool for the detection of
reactive metabolites.

QA-GSH is a novel quaternary ammonium glutathione analogue conjugating agent
described by Soglia, et al.1 Developed by Pfizer, this compound can provide
semiquantitative assessment of the bioactivation potential in vitro. for
semiquantitative LC-MS/MS detection of reactive metabolite. The methodology is well
suited for use in early drug discovery high throughput screening paradigms.

QA-GSH is available from AnaSpec, a leading provider of integrated proteomics
solutions.

For more information visit www.anaspec.com

Company Info

AnaSpec, Inc. is a leading provider of integrated proteomics solutions to
pharmaceutical, biotech, and academic research institutions throughout the world.
With a vision for innovation through synergy, AnaSpec focuses on three core
technologies: peptides, detection reagents (dyes, assay kits, & antibodies), and
combinatorial chemistry. Established in 1993, AnaSpec\'s ISO9001:2000 certified
headquarters and manufacturing facilities are located in San Jose, CA.

Reference:
1. Soglia, J.R.; G. Contillo, L.G.; Kalgutkar, A.S.; Zhao, S.; Hop, C.E.C.A.; Boyd,
J.G.; Cole, M.J. A semiquantitative method for the determination of reactive
metabolite conjugate levels in vitro utilizing liquid chromatography-tandem mass
spectrometry and novel quaternary ammonium glutathione analogues, Chem. Res.
Toxicol. 2006, 19, 480-490


Web Site = http://www.anaspec.com

Contact Details = 2149 O\'toole Ave.
San Jose, CA 95131
1-408-452-5055
ping@anaspec.com